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    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Medicine

    Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

    Robert N Helsley, Tatsunori Miyata ... Jonathan Mark Brown
    The gut microbe-derived metabolite trimethylamine (TMA) is elevated in patients with alcohol-associated hepatitis and inhibition of the gut microbial enzymes that produce TMA may serve as a tractable therapeutic strategy for the treatment of ethanol-induced liver injury.
    1. Neuroscience

    Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys

    Davide Folloni, Jerome Sallet ... Rogier B Mars
    Amygdala/temporal-prefrontal cortex fibers are organised in separate amygdalofugal and uncinate bundles in humans and macaques, shaping the anatomical foundation for decision-making and socio-emotional behaviour.
    1. Neuroscience

    Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

    Antimo Buonocore, Xiaoguang Tian ... Ziad M Hafed
    Sensory activity within the superior colliculus is read out by downstream motor structures and contributes to individual saccade kinematics with single spike precision.
    1. Medicine
    2. Neuroscience

    Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

    Roxanne Lofredi, Wolf-Julian Neumann ... Andrea A Kühn
    Bradykinesia in Parkinson's disease may be associated to a dopamine-dependent recruitment failure of subthalamic activity in short bursts of gamma synchrony.
    1. Computational and Systems Biology
    2. Neuroscience

    Information flows from hippocampus to auditory cortex during replay of verbal working memory items

    Vasileios Dimakopoulos, Pierre Mégevand ... Johannes Sarnthein
    Precisely tracking the anatomical sources of neural computations infers functional directed connectivity between hippocampal memory neurons and cortical sensory neurons, it reveals information flowing from cortex to hippocampus during encoding but the reverse direction during maintenance.
    1. Ecology
    2. Plant Biology

    Wild cereal grain consumption among Early Holocene foragers of the Balkans predates the arrival of agriculture

    Emanuela Cristiani, Anita Radini ... Dušan Borić
    A consistent pattern of consumption of Triticeae tribe grasses documented in the Danube Gorges of the Balkans since the Early Mesolithic might have facilitated a quick uptake of domesticated cereals due to a developed cultural taste and specific stone tool processing technology.
    1. Neuroscience

    Feedforward motor information enhances somatosensory responses and sharpens angular tuning of rat S1 barrel cortex neurons

    Mohamed Khateb, Jackie Schiller, Yitzhak Schiller
    Primary motor cortex afferents supra-linearly amplify the responses and sharpen angular tuning of neurons in the S1 barrel cortex.
    1. Neuroscience

    Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe

    Ai Phuong S Tong, Alex P Vaz ... Kareem A Zaghloul
    A continuum of ripple oscillations in human anterior temporal lobe reflects the dynamic synchrony of populations of neurons during memory retrieval.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang, Ji Won Oh ... Maksim V Plikus
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.