Browse the search results

Page 2 of 4
    1. Neuroscience

    Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment

    Vasin Dumrongprechachan, Ryan B Salisbury ... Yevgenia Kozorovitskiy
    A Cre-dependent reporter mouse line is generated, validated, and used to map cell-type-specific proteome and phosphoproteome of corticostriatal projections across postnatal development.
    1. Developmental Biology
    2. Neuroscience

    Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

    Emeric Merour, Hatem Hmidan ... Carlos Parras
    A comprehensive analysis of Tensin3 function in oligodendrogenesis links the fields of transcriptional control in oligodendrocyte lineage cells with morphogenetic changes and integrin signaling mediated cell survival.
    1. Cancer Biology
    2. Computational and Systems Biology

    Machine learning-assisted elucidation of CD81–CD44 interactions in promoting cancer stemness and extracellular vesicle integrity

    Erika K Ramos, Chia-Feng Tsai ... Huiping Liu
    Machine learning-assisted experiments reveal CD81 as a novel binding partner of CD44 in driving cancer stemness, tumor cell clustering, and extracellular vesicle integrity in human and mouse breast cancer.
    1. Cell Biology

    Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

    Wenyang Li, Jennifer Y Chen ... Alan C Mullen
    A high-throughput small molecule screen defined compounds that inactivate primary human hepatic stellate cells (HSCs) and led to the identification of nanchangmycin, which regulates intracellular Ca2+ levels and the activity of multiple kinases to control HSC fibrotic activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

    Lindsay B Case, Milagros De Pasquale ... Michael K Rosen
    Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

    Gabriela C Olivera, Emily C Ross ... Antonio Barragan
    The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim, Carmen Reinhard, Christof Niehrs
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.
    1. Neuroscience

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    Gustavo Della-Flora Nunes, Emma R Wilson ... M Laura Feltri
    mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

    Stephan Wilmes, Polly-Anne Jeffrey ... Ignacio Moraga
    IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
    1. Cell Biology
    2. Computational and Systems Biology

    Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

    Alfonso Bolado-Carrancio, Oleksii S Rukhlenko ... Boris N Kholodenko
    Different RhoA and Rac1 dynamics at the cell front and rear are coordinated through periodic GTPase waves, which define the minimal autonomous biochemical machinery necessary and sufficient for cell migration.