Machine learning-assisted experiments reveal CD81 as a novel binding partner of CD44 in driving cancer stemness, tumor cell clustering, and extracellular vesicle integrity in human and mouse breast cancer.
Simona Bolamperti, Hiroaki Saito ... Hanna Taipaleenmäki
A novel mechanism underlying the regulation of osteoblast morphology, adherence, and migration that has implications in bone remodeling, regeneration, and response to the pharmacological effects of PTH treatment.
NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
A comprehensive analysis of Tensin3 function in oligodendrogenesis links the fields of transcriptional control in oligodendrocyte lineage cells with morphogenetic changes and integrin signaling mediated cell survival.
Integrin a11 is identified as an Osteolectin receptor, revealing a new mechanism for adult skeletal bone maintenance in which Osteolectin/a11b1 signaling promotes bone formation by activating the Wnt pathway.
Raul Araya-Secchi, Katrine Bugge ... Birthe B Kragelund
The prolactin receptor, Janus kinase 2, and PI(4,5)P2 form a co-structure with the membrane resulting in orientations with different accessibility fixing the disordered juxtamembrane domain of the receptor in an extended structure.
EphB4 maintains critical functional properties of the adult cardiac vasculature, namely mechanical resistance and fatty acid transport capability, and thereby prevents dilated cardiomyopathy-like defects.
Mechanosensitive channels Piezo1/2 are required for osteoblast differentiation from progenitors by sensing fluid sheer stress and matrix rigidity and regulating NFATc1, YAP1 and ß-catenin activities through Ca2+ stimulated phosphatase calcineurin.
