11,457 results found
    1. Cancer Biology
    2. Cell Biology

    Junction Mapper is a novel computer vision tool to decipher cell–cell contact phenotypes

    Helena Brezovjakova et al.
    Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
    1. Stem Cells and Regenerative Medicine

    Stem cells repurpose proliferation to contain a breach in their niche barrier

    Kenneth Lay et al.
    Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
    1. Stem Cells and Regenerative Medicine

    Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

    Francis Grafton et al.
    Deep learning combined with induced pluripotent stem cell technology is an effective method to interrogate cellular phenotypes and predict patterns of cardiotoxicity in vitro.
    1. Neuroscience

    Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

    José Antonio Pérez-Escobar et al.
    The firing rate of MEC neurons conveys information about visual landmarks.
    1. Physics of Living Systems

    Polar pattern formation induced by contact following locomotion in a multicellular system

    Masayuki Hayakawa et al.
    Transient cell-cell contact of eukaryotic cells, called contact following locomotion, causes cell density segregation, and its high-density region traveled as a band within the disordered background.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Developmental Biology

    Cytoneme-mediated cell-cell contacts for Hedgehog reception

    Laura González-Méndez et al.
    Direct interaction between Hedgehog-sending and Hedgehog-receiving cytonemes is a fundamental mechanism for morphogen transfer and gradient establishment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

    Suzanne PM Welten et al.
    Redundancy in the costimulatory signals that drive CD8+ T cell expansion is dictated by pathogen-specific cues.
    1. Cell Biology

    Automated cell-type classification in intact tissues by single-cell molecular profiling

    Monica Nagendran et al.
    The ability to rapidly stain for any combination of genes in intact tissue with automated quantification of transcripts in individual cells and spatial re-mapping affords new insights into lung biology, and will greatly accelerate progress in scientific and medical research.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui et al.
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.

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