2,558 results found
    1. Ecology
    2. Evolutionary Biology

    Caterpillar-induced rice volatiles provide enemy-free space for the offspring of the brown planthopper

    Xiaoyun Hu et al.
    The brown planthopper has evolved a highly adaptive oviposition strategy by exploiting caterpillar-induced plant volatiles that provide safe havens for its offspring.
    1. Human Biology and Medicine

    Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes

    Mi Lai et al.
    Lipid dysmetabolism occurs at postpartum in women who progress from GDM to type 2 diabetes, and specific lipids could predict the progression.
    1. Developmental Biology
    2. Immunology and Inflammation

    Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

    Chew Leng Lim et al.
    Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.
    1. Neuroscience

    Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

    Cristina Blázquez et al.
    Δ9-Tetrahydrocannabinol impairs motor coordination in mice by inhibiting autophagy in the striatonigral pathway, thus defining a new conceptual view of how cannabis acts in the brain.
    1. Biochemistry and Chemical Biology

    Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

    Sandy Mattijssen et al.
    LARP4 protects mRNAs against deadenylation over a wide range of poly(A) lengths but with most apparent functional impact on short lengths known to sensitize PABP binding and mRNA stability.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis

    Tatsuhisa Tsuboi et al.
    Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.
    1. Computational and Systems Biology

    Stochastic logistic models reproduce experimental time series of microbial communities

    Lana Descheemaeker, Sophie de Buyl
    Properties of various microbial communities time series, such as the noise color and neutrality, are captured by stochastic generalized Lotka-Volterra equations, even in the absence of interactions.
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

    Michael R Garvin et al.
    Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.
    1. Microbiology and Infectious Disease

    Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

    Giancarlo Noe Bruni, Joel M Kralj
    Aminoglycosides are a class of antibiotics that can kill Escherichia coli by building up internal voltage through disrupting the normal consumption of ATP.
    1. Cancer Biology

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Allison N Lau et al.
    Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.

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