2,722 results found
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert et al.
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward et al.
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
    1. Plant Biology

    A lectin receptor kinase as a potential sensor for extracellular nicotinamide adenine dinucleotide in Arabidopsis thaliana

    Chenggang Wang et al.
    Genetic and biochemical analyses demonstrate that cell-surface lectin receptors can potentially function as extracellular NAD+-binding receptors and provide direct evidence for extracellular NAD+ being a bona fide endogenous signaling molecule in plants.
    1. Structural Biology and Molecular Biophysics

    Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family

    Stefan Brückner et al.
    Structural, biophysical and physiological analysis reveals how yeast cell surface adhesins evolved to confer self-nonself discrimination in single cells and whole populations.
    1. Cell Biology

    Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin

    Shunbun Kita et al.
    Binding study of native adiponectin existing in serum supported the importance of T-cadherin but not AdipoRs nor calreticulin.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila

    Shouqiang Cheng et al.
    Fly protein families Dprs and DIPs can create a multitude of complementary interfaces for homo- and heterophilic adhesion complexes, resulting in instructive roles for connectivity in the motor neuron circuitry.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

    Neel H Shah et al.
    A high-throughput technique to characterize the substrate specificities of tyrosine kinases identifies the key features of kinases and substrates that enforce accurate signaling from T cell receptors.
    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash et al.
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
    1. Cell Biology

    Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

    Eszter Zavodszky, Ramanujan S Hegde
    ER-resident chaperones and cargo receptors make excursions to the cell surface and endocytic compartments when they accompany misfolded clients to lysosomes for degradation.
    1. Biochemistry and Chemical Biology

    Mechano-redox control of integrin de-adhesion

    Freda Passam et al.
    Ligand binding, force and chemistry combine to control the function of a cell surface receptor.

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