A model of hippocampal replay is proposed that gives a biologically plausible account of how the hippocampus could prioritize replay and produce a variety of different replay statistics, and is efficient in driving spatial learning.

A novel tool enables cross-checking the quality of replay events and evaluating the effectiveness of a given replay detection method in the absence of a ground truth.

Experimental determination of residue contacts from mutational data allows model discrimination and identification of in vivo functional conformations of proteins.

Motor context and mechanosensory feedback together influence how flies control head movements during visually guided flight maneuvers.

The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.

The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.

Emergent property inference, a novel machine learning methodology, learns distributions of neural circuit model parameters that produce computational properties and provides novel scientific insight through the quantification of the rich parametric structure it captures.

Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.

The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.

The treeline follows climate warming with a severe time lag, but migration rates are increasing so that only under ambitious mitigation efforts will 30% of original tundra areas remain in the north in the long run.