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    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain, Carl N Wivagg ... Ethan C Garner
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Microbiology and Infectious Disease

    Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus

    Juan-Carlos García-Betancur, Angel Goñi-Moreno ... Daniel Lopez
    During Staphylococcus aureus infections, bacterial cells bifurcate into distinct, specialized cell types that localize physically in different colonization tissues to simultaneously generate different infection types.
    1. Microbiology and Infectious Disease

    Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

    Ashelyn E Sidders, Katarzyna M Kedziora ... Brian P Conlon
    Palmitoleic acid not only potentiates vancomycin killing of Gram-positive bacteria, but the insertion of palmitoleic acid into the membrane leads to the unexpected accumulation of membrane-bound cell wall precursors, representing a novel mechanism of action for unsaturated fatty acids.
    1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel, Heng Zhao, John D Helmann
    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.
    1. Microbiology and Infectious Disease

    Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

    Jennifer A Taylor, Benjamin P Bratton ... Nina R Salama
    The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system

    Magda Luciana Atilano, Pedro Matos Pereira ... Sérgio Raposo Filipe
    To avoid recognition by the immune system, bacteria use autolysins to trim fragments of peptidoglycans that are exposed on the bacterial cell wall.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

    Vivek V Thacker, Neeraj Dhar ... John D McKinney
    Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
    1. Cell Biology
    2. Immunology and Inflammation

    CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation

    Francesco Andreata, Marc Clément ... Giuseppina Caligiuri
    CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.
    1. Cell Biology
    2. Plant Biology

    Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

    Yuan Zhou, Prativa Amom ... Anna A Dobritsa
    Pollen aperture patterning in Arabidopsis is controlled by members of the ELMOD protein family, whose expression levels in developing pollen lineage are tightly regulated.
    1. Microbiology and Infectious Disease

    Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius

    Alan M O'Neill, Kate A Worthing ... Richard L Gallo
    The discovery and development of a feline skin commensal bacterium for bacteriotherapy against skin disease, that could benefit patients due to established low cytotoxicity, broad-spectrum antimicrobial activity and anti-inflammatory activity.