9,228 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects

    Antoine Vigouroux et al.
    Class-A penicillin-binding proteins are dispensable for rod-like cell-shape but essential for mechanical integrity by sensing and repairing cell-wall defects locally, as investigated in the model system Escherichia coli.
    1. Ecology
    2. Neuroscience

    Patterns of call communication between group-housed zebra finches change during the breeding cycle

    Lisa F Gill et al.
    Call-based vocal communication of individually recorded zebra finches changes in social groups across reproductive stages and is related with successful egg laying.
    1. Neuroscience

    Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

    Chiara La Rosa et al.
    The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
    1. Cell Biology

    Intraflagellar transport drives flagellar surface motility

    Sheng Min Shih et al.
    The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

    Mona Seifert et al.
    High-throughput and ultra-stable magnetic tweezers reveal that Remdesivir induces a long-lived backtrack pause upon incorporation by the coronavirus polymerase, and SARS-CoV-2 is able to evade interferon-induced antiviral ddhCTP.
    1. Cancer Biology

    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

    Carlos J Diaz Osterman et al.
    Genomic gains in ovarian cancer can promote cisplatin resistance via a FAK, Wnt/beta-catenin and Myc signaling pathway supporting pluripotency genes and tumorspheres that can acquire FAK dependence for survival.
    1. Chromosomes and Gene Expression

    Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

    Nina Kirstein et al.
    Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.
    1. Physics of Living Systems

    Single molecule microscopy reveals key physical features of repair foci in living cells

    Judith Miné-Hattab et al.
    Upon DNA damage, Rad52 forms a membraneless sub-compartment where Rad52 molecules are highly dynamic and share properties with liquid-liquid phase-separated molecules, reflecting the existence of a liquid droplet around damaged DNA.
    1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha et al.
    Quantitative measurement of epigenetic memory and inheritance dynamics.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.

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