2,758 results found
    1. Neuroscience

    Development of schemas revealed by prior experience and NMDA receptor knock-out

    George Dragoi, Susumu Tonegawa
    Novel spatial representations by hippocampal cellular assemblies develop on the framework of preconfigured hippocampal networks whose homeostatic synaptic reorganization is accelerated by prior experience and CA3 NMDAR-dependent plasticity.
    1. Structural Biology and Molecular Biophysics

    Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

    Lars-Anders Carlson et al.
    In vitro reconstitution shows how HIV-1 Gag assemblies on membranes can package the RNA genome in the presence of a vast excess of competing cellular RNAs, and that selectivity and immature lattice assembly are deeply intertwined with one another.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic et al.
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Biochemistry and Chemical Biology

    Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

    Marta Carroni et al.
    Head-to-head interactions of regulatory coiled-coil domains control activity of the central bacterial AAA+ protein ClpC by promoting formation of a reversible resting state.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

    Andrei Vovk et al.
    Simple biophysical considerations explain the collective behavior of molecularly diverse complex protein assemblies that regulate transport between the nucleus and the cytoplasm in eukaryotic organisms.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Mapping single-cell atlases throughout Metazoa unravels cell type evolution

    Alexander J Tarashansky et al.
    Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai et al.
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Efficient support of virus-like particle assembly by the HIV-1 packaging signal

    Mauricio Comas-Garcia et al.
    The packaging signal in HIV-1 genomic RNA supports in vitro particle assembly more efficiently than control RNAs, probably explaining its selective packaging during virus assembly in vivo.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

    Lucie Zilova et al.
    Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.

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