Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
G Larisa Maier, Nikita Komarov ... Simon G Sprecher
Drosophila larvae show taste multimodality and combinatorial sensing at gustatory organ level but also systemically as they employ complementary external and internal taste in sugar detection.
Tobias X Dong, Shivashankar Othy ... Michael D Cahalan
Salsa6f is a novel, ratiometric genetically encoded Ca2+ indicator that combines the power of ratiometric chemical Ca2+ indicators with the ability, when expressed transgenically, to image cellular Ca2+ signals amid complex tissue environments in vivo.
Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
The ability of calcium waves to exert different effects on calcineurin activity depending on subcellular location is mediated by the distribution of calmodulin.
In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integration of time and space.