Distinct phosphorylations of Akt determine the regulation of glucose uptake into fat and epithelial cells, revealing unexpected specialization in both Akt activation and its downstream control of glucose metabolism.
Valentina Baldazzi, Delphine Ropers ... Hidde de Jong
A coarse-grained model of microbial growth coupling fluxes of carbon and energy shows that resource allocation is a major explanatory factor of the observed variability of growth rates and growth yields across different bacterial strains.
Anamika Agrawal, Gulcin Pekkurnaz, Elena F Koslover
A quantitative analysis of glucose-dependent transport regulation indicates that mitochondrial accumulation in regions of high nutrient availability can enhance metabolism in neuronal axons under physiologically relevant conditions.
Yongjin Xu, Richard M Bergenstal ... Ramzi A Ajjan
The person-specific adjusted HbA1c addresses non-glycaemic variation in laboratory HbA1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.
Simeon Leupold, Georg Hubmann ... Matthias Heinemann
With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
Marian Breuer, Tyler M Earnest ... Zaida Luthey-Schulten
A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.