1,897 results found
    1. Cell Biology

    Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

    Muheeb Beg, Nazish Abdullah ... Timothy E McGraw
    Distinct phosphorylations of Akt determine the regulation of glucose uptake into fat and epithelial cells, revealing unexpected specialization in both Akt activation and its downstream control of glucose metabolism.
    1. Computational and Systems Biology

    Resource allocation accounts for the large variability of rate-yield phenotypes across bacterial strains

    Valentina Baldazzi, Delphine Ropers ... Hidde de Jong
    A coarse-grained model of microbial growth coupling fluxes of carbon and energy shows that resource allocation is a major explanatory factor of the observed variability of growth rates and growth yields across different bacterial strains.
    1. Physics of Living Systems

    Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation

    Anamika Agrawal, Gulcin Pekkurnaz, Elena F Koslover
    A quantitative analysis of glucose-dependent transport regulation indicates that mitochondrial accumulation in regions of high nutrient availability can enhance metabolism in neuronal axons under physiologically relevant conditions.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Addressing shortfalls of laboratory HbA1c using a model that incorporates red cell lifespan

    Yongjin Xu, Richard M Bergenstal ... Ramzi A Ajjan
    The person-specific adjusted HbA1c addresses non-glycaemic variation in laboratory HbA1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic, Clément Vulin ... Pascal Hersen
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Cell Biology

    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

    Arpit Sharma, Lalita Oonthonpan ... Eric B Taylor
    Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.
    1. Cell Biology
    2. Computational and Systems Biology

    Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

    Simeon Leupold, Georg Hubmann ... Matthias Heinemann
    With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer, Tyler M Earnest ... Zaida Luthey-Schulten
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
    1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diabetes regulates fructose absorption through thioredoxin-interacting protein

    James R Dotimas, Austin W Lee ... Richard T Lee
    Thioredoxin-Interacting Protein binds directly to fructose transporters and regulates fructose metabolism, both acutely and chronically.

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