293 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    An image-based data-driven analysis of cellular architecture in a developing tissue

    Jonas Hartmann, Mie Wong ... Darren Gilmour
    A computational strategy for extracting representative numerical features from 3D microscopy data enables in-depth quantitative analysis of cell and tissue organization through machine learning-driven data integration and context-guided visualization.
    1. Neuroscience

    Learning-related contraction of gray matter in rodent sensorimotor cortex is associated with adaptive myelination

    Tomas Mediavilla, Özgün Özalay ... Daniel J Marcellino
    Learning produces dynamic white matter volumetric changes in the rodent brain observed by voxel-based morphometry on longitudinal structural MRI for which estimated white matter volume reflects adaptive myelination in the cortex.
    1. Neuroscience

    Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

    Cesar Nava Gonzales, Quintyn McKaughan ... Chih-Ying Su
    A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.
    1. Developmental Biology
    2. Evolutionary Biology

    Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

    Colton M Unger, Jay Devine ... Campbell Rolian
    Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

    Massimo Ganassi, Sara Badodi ... Simon M Hughes
    Cellular and molecular analyses reveal how Myogenin controls muscle stem cell quiescence and growth of adult muscle fibres.
    1. Neuroscience

    Quantitative MRI reveals differences in striatal myelin in children with DLD

    Saloni Krishnan, Gabriel J Cler ... Kate E Watkins
    A new quantitative MRI protocol reveals reduced myelin in the striatum in children with developmental language disorder, shedding light on the brain basis of this disorder.
    1. Developmental Biology
    2. Evolutionary Biology

    A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis

    Jaaved Mohammed, Neha Arora ... Joanna Wysocka
    SNP-editing of human embryonic stem cells reveals cell type specific function of a genetic variant associated with changes in human jaw shape.
    1. Neuroscience

    Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain

    Sean Froudist-Walsh, Philip GF Browning ... Paula L Croxson
    Brain recovery after injury can be predicted based on its activity and structure, which may allow us to understand why some brain injuries lead to permanent loss of cognitive function, while others do not.
    1. Developmental Biology

    Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification

    Imran S Khan, Christopher Molina ... Dean Sheppard
    Reduced lung myofibroblast proliferation is a unifying feature in multiple models of developmental emphysema and inhibition of myofibroblast proliferation is sufficient to cause this pathology.
    1. Neuroscience
    2. Evolutionary Biology

    The first complete 3D reconstruction and morphofunctional mapping of an insect eye

    Anastasia A Makarova, Nicholas J Chua ... Alexey A Polilov
    Not revised
    Reviewed Preprint v1

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