3,152 results found
    1. Developmental Biology
    2. Neuroscience

    Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

    Geoffrey MW Cook et al.
    The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
    1. Cell Biology
    2. Neuroscience

    Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

    Julie Bruyère et al.
    Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
    1. Neuroscience

    Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits

    Viktor János Oláh et al.
    Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure

    Sarah Jacquelyn Smith et al.
    A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.
    1. Immunology and Inflammation

    Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

    Theresa Benezeder et al.
    Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
    1. Neuroscience

    MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

    Ying Zhang et al.
    Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in α2-containing GABAA receptors.
    1. Structural Biology and Molecular Biophysics

    ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

    Horia Vais et al.
    Calcium release from the endoplasmic reticulum through the IP3 receptor ion channel is strongly regulated by a calcium-binding protein in the lumen of the endoplasmic reticulum.
    1. Cell Biology

    Bmal1 integrates mitochondrial metabolism and macrophage activation

    Ryan K Alexander et al.
    Macrophage Bmal1 controls the timing of the glycolytic to oxidative metabolism transition that dictates the extent of Hif-1a activation and the associated inflammatory response.

Refine your results by:

Type
Research categories