3,061 results found
    1. Computational and Systems Biology

    Distributing tasks via multiple input pathways increases cellular survival in stress

    Alejandro A Granados et al.
    Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Distinct transcriptional responses elicited by unfolded nuclear or cytoplasmic protein in mammalian cells

    Yusuke Miyazaki et al.
    A new unfolded protein response has been discovered that is distinct from the heat shock response and protects mammalian cells from proteotoxic stress.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    New insights into the cellular temporal response to proteostatic stress

    Justin Rendleman et al.
    A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
    1. Cell Biology
    2. Computational and Systems Biology

    Nonlinear feedback drives homeostatic plasticity in H2O2 stress response

    Youlian Goulev et al.
    Nonlinear H2O2 scavenging by peroxiredoxins drives acquired stress resistance and replicative lifespan hormesis.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Hsp70-associated chaperones have a critical role in buffering protein production costs

    Zoltán Farkas et al.
    Protein biosynthesis and protein quality control jointly determine protein production costs.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral et al.
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Cell Biology

    Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

    Mei Rosa Ng et al.
    The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.
    1. Cell Biology
    2. Genetics and Genomics

    Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells

    Neel S Singhal et al.
    A genetic basis underlying cell resilience against metabolic stress in cells of a hibernator, Arctic ground squirrels, has been discovered.
    1. Microbiology and Infectious Disease

    Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

    Myra Hosmillo et al.
    A key cellular stress granule protein, G3BP1, is critical for efficient norovirus infection, representing the first pan-norovirus, pro-viral factor identified to date.
    1. Computational and Systems Biology
    2. Developmental Biology

    Why plants make puzzle cells, and how their shape emerges

    Aleksandra Sapala et al.
    Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.

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