Cellular stress induces RNA decay that depends on stress granule assembly and is mediated by XRN1, independent of poly(A) tail and 5' cap removal.

A new unfolded protein response has been discovered that is distinct from the heat shock response and protects mammalian cells from proteotoxic stress.

A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.

Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.

Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.

Counterintuitively, activation of the transcriptional repressor of growth-promoting genes is important for yeast cell acclimation to salt stress, such that cells with larger activation of the repressor tend to have faster growth acclimation after stress.

Acetate concentration, which is significantly increased in association with energy stresses such as those that occur with diabetes or starvation, is emerging as a novel 'ketone body' with potential as a parameter for evaluating the progression of energy stress.

Aging is associated with stress-induced senescence of adipose stromal cells, leading to impaired adipogenesis, oxidative stress, mitochondrial dysfunction, and insulin resistance, all being alleviated by metformin treatment of adipose stromal cells.

Disruption of the intracellular vimentin network upon cellular stress results in enhanced cell surface vimentin on human osteoarthritic chondrocytes and might represent a novel membrane-associated marker of stress-induced premature senescence.

The immune effector Drosomycin buffers stress signaling in hypertrophic salivary glands to inhibit their disintegration, detection by the cellular immune response, and promotes further overgrowth.