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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

    Eyal Paz, Sahil Jain ... Abdussalam Azem
    TIM23 core deficiency specifically impacts the oxidative phosphorylation and the mitochondrial ribosome complexes and, unexpectedly, leads to reduction of plasma membrane voltage-dependent potassium channels in neurons.
    1. Cell Biology

    UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

    Satoshi Ninagawa, Masaki Matsuo ... Kazutoshi Mori
    The fate of glycoproteins in the endoplasmic reticulum whether they are directed toward folding or targeted to degradation depends on a tug of war between UGGT1 and EDEM family proteins.
    1. Neuroscience

    Modulation of RNA processing genes during sleep-dependent memory

    Yongjun Li, Nitin S Chouhan ... Amita Sehgal
    RNA processing genes regulated during sleep-dependent memory may contribute to sleep and memory.
    1. Developmental Biology
    2. Neuroscience

    Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

    Denise M Poltavski, Alexander T Cunha ... Takako Makita
    Neural crest and placode lineages both contribute to the enteric nervous system, divergently utilizing Edn3-Ednrb and GDNF-Ret signaling.
    1. Evolutionary Biology

    Biases of Principal Component Analysis (PCA) in Physical Anthropology Studies Require a Reevaluation of Evolutionary Insights

    Nima Mohseni, Eran Elhaik
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

    Typhaine Comyn, Thomas Preat ... Pierre-Yves Plaçais
    In neurons of the Drosophila brain’s memory center, PKCδ relays a post-learning dopamine signal to mitochondria, boosting their metabolic activity and thereby unlocking long-term memory formation.
    1. Cell Biology
    2. Developmental Biology

    Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
    Modulation of division plane rotation in proliferating chondrocytes determines the ratio of clusters and columns, which may support the multifunctional design of the growth plate.
    1. Evolutionary Biology

    Coenzyme-Protein Interactions since Early Life

    Alma Carolina Sanchez-Rocha, Mikhail Makarov ... Klára Hlouchová
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René A Frank
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Evolutionary Biology

    Refining the resolution of the yeast genotype-phenotype map using single-cell RNA-sequencing

    Arnaud N’Guessan, Wen Yuan Tong ... Alex N Nguyen Ba
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing