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T. gondii infection alters how peptide ligands are presented to the immune system by inducing a previously unreported structural change in Human Leukocyte Antigens (HLAs).

Dpp emanating from the anterior-posterior compartment boundary is continuously required to promote proliferative growth of the whole fly wing appendage.

CHK2 directly binds the AR to mediate transient suppression of AR activity and thus loss of CHK2 function in prostate cancer increases AR activity, DNA damage response and radiation resistance.

NODAL/Activin-induced SMAD2 binding directly drives remodeling of both open and closed chromatin and does not directly correlate with temporal patterns of gene expression upon prolonged signaling.

The fate of glycoproteins in the endoplasmic reticulum whether they are directed toward folding or targeted to degradation depends on a tug of war between UGGT1 and EDEM family proteins.

Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.

An aspartyl protease is essential for the lytic cycle of Toxoplasma gondii and is involved in the maturation of proteins critical for invasion and egress, and it can be targeted selectively with an ethylamine scaffold based peptidomimetic inhibitor.

A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.

Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.