8 results found
    1. Cell Biology

    CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

    Kian-Yong Lee et al.
    The CYK-4 subunit of the broadly conserved intercellular bridge component centralspindlin, but not its ZEN-4 subunit, is essential for the cytokinesis-like closure of intercellular bridges that cellularizes oocytes to separate them from germline syncytia.
    1. Cell Biology

    The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

    Donglei Zhang, Michael Glotzer
    Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.
    1. Cell Biology

    Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis

    Vikash Verma, Thomas J Maresca
    MT plus-end-mediated recruitment of a cortical pool of ECT2 trigger RhoA activation upon contact, which results in localized contractility during cytokinesis.
    1. Structural Biology and Molecular Biophysics

    Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A

    Sithara Wijeratne, Radhika Subramanian
    Geometrical features of microtubule arrays regulate the collective activity of motor and non-motor proteins.
    1. Structural Biology and Molecular Biophysics

    The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

    Joseph Atherton et al.
    MKLP2 is a divergent molecular motor that has structurally evolved to bind its microtubule track and use the energy of ATP in distinct ways, tuned according to its function in cell division.
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe et al.
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Physics of Living Systems
    2. Cell Biology

    Cortical flow aligns actin filaments to form a furrow

    Anne-Cecile Reymann et al.
    Compressing the actomyosin network by cortical flow causes filaments to align and form a constricting ring.
    1. Cell Biology
    2. Computational and Systems Biology

    A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans

    Renat N Khaliullin et al.
    Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.

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