228 results found
    1. Cell Biology

    Cell Division: How centrioles acquire the ability to reproduce

    Midori Ohta et al.
    A protein called SAS-7 is required for daughter centrioles to become mothers in C. elegans.
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    1. Cell Biology

    Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

    Kenji Sugioka et al.
    A genetic screen and live cell imaging show that a newly identified coiled-coil protein called SAS-7 is the earliest acting factor in centriole assembly yet identified in the roundworm Caenorhabditis elegans.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

    Matthew A Cottee et al.
    The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

    Kacper B Rogala et al.
    SAS-5 forms oligomers, through a trimeric coiled coil and novel dimeric domain, that are necessary for centriolar localisation of SAS-5 and for centriole duplication.
    1. Cell Biology

    A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells

    Ewelina Betleja et al.
    Cells have evolved a mechanism that actively regulates centriole maturation during quiescence.
    1. Cell Biology

    PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

    Andrew Michael Sydor et al.
    The previously uncharacterized protein PPP1R35 is a novel centriolar luminal protein critical for centriole elongation by acting in a complex with microcephaly protein RTTN.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

    Christian Arquint et al.
    Binding of STIL to PLK4's characteristic Polo-box 3 links PLK4 kinase activation to STIL self-association and is a crucial regulatory step for the localized recruitment of downstream factors in centriole duplication.
    1. Cell Biology
    2. Developmental Biology

    Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

    Andrew Kodani et al.
    To control centriole duplication, centriolar satellite proteins assemble a microcephaly-associated protein complex at the centrosome and activate cyclin-dependent kinase 2.
    1. Cell Biology

    De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

    Won-Jing Wang et al.
    Canonical centriole duplication is much less prone to errors than de novo synthesis of centrioles, but neither depends on self-oligomerization of the centriole protein SAS-6.
    1. Cell Biology

    Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

    Jennifer T Wang et al.
    Deletion of delta-tubulin or epsilon-tubulin in human cells results in loss of centriolar triplet microtubules and defects in centriole structure and inheritance.

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