232 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

    Jan Wisniewski et al.
    Internally tagged, functional Cse4/CENP-A/CenH3 histone variant is exclusively centromeric and stable through the budding yeast cell cycle after replacement in S phase.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell et al.
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Cell Biology

    The quantitative architecture of centromeric chromatin

    Dani L Bodor et al.
    The number of CENP-A molecules at human centromeres helps to explain how this structure is built and epigenetically inherited.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA

    Sasha A Langley et al.
    Genomic polymorphism across centromeric regions of humans is organized into large-scale haplotypes with great diversity, including entire Neanderthal centromeres.
    1. Cell Biology

    Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

    Giulia Vallardi et al.
    Distinct PP2A-B56 complexes use isoform-selective interactions to localise to either the centromere or kinetochore and control different processes during mitosis.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Decoding the centromeric nucleosome through CENP-N

    Satyakrishna Pentakota et al.
    A comprehensive structural, biochemical, and cell biological analysis reveals the molecular mechanism and significance of the conserved interaction of centromeric protein N (CENP-N) with the centromeric nucleosome.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Holocentromeres are dispersed point centromeres localized at transcription factor hotspots

    Florian A Steiner, Steven Henikoff
    Worm holocentromeres show a polycentric distribution, with each site containing a single centromeric nucleosome and also being targeted by multiple transcription factors.
    1. Chromosomes and Gene Expression

    The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

    Steven Henikoff et al.
    A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

    Gemma LM Fisher et al.
    A combination of structural, biochemical, single-molecule and in vivo methods are used to show how ParB locally condenses the bacterial chromosome near the origin and earmarks this region for segregation.
    1. Cell Biology

    Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

    Marco Novais-Cruz et al.
    Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.

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