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The anaphase promoting complex (APC) has an essential role in ubiquitin-mediated proteolysis in the disassembly of cilia.

An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.

Tumor Protein p53 Binding Protein 1 and Ubiquitin Specific Peptidase 28 engage p53 to promote mitotic efficiency.

Molecular and cell biology analyses reveal novel roles of Polo-like kinases in establishing non-random segregation patterns of spindle-associated microtubule-organizing centers during mitosis, a phenomenon linked with replicative cell aging.

Inhibition of the catalytic activity of the Zap70 kinase reveals that discrete TCR-regulated events control the remodelling of the actin cytoskeleton when the cytotoxic T cell interacts with its target.

HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.

In response to proteotoxic stress, squamous cell carcinoma cells hijack the integrated stress response to promote recovery by bolstering protection of microtubule dynamics.

Mammal hearts are unable to replace lost cardiomyocytes, which may be due to the loss of centrosome integrity in these cells after birth.

Non-centrosomal microtubule nucleation mediated by augmin is essential for neural progenitor mitosis and survival, and thus brain development.

The previously uncharacterized protein PPP1R35 is a novel centriolar luminal protein critical for centriole elongation by acting in a complex with microcephaly protein RTTN.