253 results found
  1. Event Report: A second Aging, Geroscience and Longevity Symposium

    Catch up on our second online symposium in which eLife authors showcased their research published in the Aging, Geroscience and Longevity Special Issue.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis

    Alisa Atkins et al.
    The structural maintenance of chromosomes complex, SMC5/6, is crucial for brain development and function as it ensures proficient DNA replication in neural progenitor cells prior to chromosome segregation.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth et al.
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Developmental Biology

    Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway

    Elisa Nerli et al.
    A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.
    1. Cell Biology

    BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

    Laura Bel Borja et al.
    BUB-1 recruits PP2A/B56 to regulate chromosome congression in meiosis I.
    1. Cell Biology

    WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity

    Emmanuelle Steib et al.
    Centriole integrity is ensured by the connection between the inner scaffold and microtubule triplets through POC16/WDR90 proteins.
    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson et al.
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Developmental Biology

    Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish

    Craig T Jacobs, Peng Huang
    Genetic analyses combining photoconvertible cell signalling reporters with gain- and loss-of function manipulations reveal a novel role for Notch signalling in controlling Hedgehog response in neural progenitor cells.

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