228 results found
    1. Neuroscience

    Calcium dependence of neurotransmitter release at a high fidelity synapse

    Abdelmoneim Eshra et al.
    The Ca2+-dependence of vesicle priming, fusion, and replenishment at cerebellar mossy fiber boutons show a prominent Ca2+-dependent priming step, a shallow non-saturating dose-response curve up to 50 µM, and little Ca2+-dependence of sustained vesicle replenishment.
    1. Neuroscience

    Diverse inhibitory projections from the cerebellar interposed nucleus

    Elena N Judd et al.
    Inhibitory cerebellar feedback to the inferior olive is central to computational models of learning, but novel targets of these neurons identified here expand their potential roles.
    1. Neuroscience

    Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

    Anita E Autry et al.
    Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
    1. Neuroscience

    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

    Jason D Vevea et al.
    Synaptotagmin 7 is asymmetrically localized to the axonal plasma membrane through γ-secretase processing to promote vesicle docking during short-term synaptic plasticity in mouse hippocampal neurons.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden et al.
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Developmental Biology
    2. Neuroscience

    Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    Baruch Haimson et al.
    Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.
    1. Cell Biology
    2. Neuroscience

    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

    Rene Solano Fonseca et al.
    Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.
    1. Developmental Biology
    2. Evolutionary Biology

    Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

    Astrid Deryckere et al.
    Neurogenic progenitor cells surrounding the eye placode generate neurons that migrate over long distances to the developing octopus brain.
    1. Neuroscience

    Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

    Sahana Sitaraman et al.
    A protein that is a building block of intercellular bridges between neurons promotes their ability to grow dendrites and make synapses.
    1. Neuroscience

    Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

    Chong Guo et al.
    Purkinje cell collaterals regulate processing in the input layer of the cerebellum by providing fast stochastic GABAA-mediated and slow GABAB-mediated inhibition to a specialized subset of unipolar brush cells.

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