228 results found
    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm et al.
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.
    1. Neuroscience

    Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1

    Naoki Yamawaki et al.
    Cell-type-specific circuit analysis reveals a highly polysynaptic pattern of excitatory feedforward connections along the somatosensory-to-motor loop, from cuneate via VPL thalamus to S1 and M1 cortex and corticospinal neurons.
    1. Genetics and Genomics
    2. Neuroscience

    Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

    Quadri Adewale et al.
    Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager et al.
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa et al.
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Neuroscience

    Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

    Anita E Autry et al.
    Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland et al.
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Evolutionary Biology
    2. Neuroscience

    Shore crabs reveal novel evolutionary attributes of the mushroom body

    Nicholas Strausfeld, Marcel E Sayre
    Dramatic phenotypic divergence of crustacean mushroom bodies map to phylogenetic lineages, thereby offering unexplored opportunities for relating divergent cognitive centers to different ecologies and behavioral repertoires required to negotiate them.
    1. Neuroscience

    Nanodomain coupling explains Ca2+ independence of transmitter release time course at a fast central synapse

    Itaru Arai, Peter Jonas
    Ca2+ channels and release sensors at a fast central synapse are tightly coupled, which minimizes the effect of extracellular Ca2+ concentration on the timing of transmitter release.
    1. Cell Biology
    2. Genetics and Genomics

    Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

    Fabrizio Orsenigo et al.
    Single-cell RNA analysis of brain endothelium identifies the angiogenic venous capillary subset and respective resident endothelial progenitors at the origin of CCM lesions, while arterial endothelial cells are unaffected.

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