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    1. Developmental Biology
    2. Neuroscience

    Olig3 regulates early cerebellar development

    Elijah D Lowenstein, Aleksandra Rusanova ... Luis R Hernandez-Miranda
    The transcription factor Olig3 safeguards the correct specification of early born cerebellar neuron derivatives and curtails an inhibitory interneuron differentiation program.
    1. Neuroscience

    Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

    Celia Biane, Florian Rückerl ... Laurence Cathala
    Patch-clamp electrophysiology, fluorescence imaging, and computational modeling were used to identify cellular mechanisms underlying maturation of dendritic computations in interneurons.
    1. Cell Biology
    2. Neuroscience

    High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

    Daniel Medina-Cano, Ekin Ucuncu ... Vincent Cantagrel
    Impairment of protein N-glycosylation disrupts neural cell adhesion mediated by highly glycosylated members of the IgSF-CAM protein family.
    1. Neuroscience

    VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors

    Soo Ji Baek, Jin Sung Park ... Keiko Tanaka-Yamamoto
    Long-term chemogenetic manipulation of specific cerebellar pathway involving ventral tegmental area revealed a critical role of the pathway as a proactive mediator of the stress-dependent development of depression-like behaviors.
    1. Cell Biology
    2. Neuroscience

    Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

    Jinye Dai, Kif Liakath-Ali ... Thomas C Südhof
    A genetic manipulation of the Nrxn1/3SS4+-Cbln1/2 complex reveals this signaling pathway has no role in synapse formation but functions to shape the NMDAR- and AMPAR-content at multiple types of synapses with distinct facets in diverse circuits.
    1. Medicine

    Correlated signatures of social behavior in cerebellum and anterior cingulate cortex

    Sung Won Hur, Karen Safaryan ... Peyman Golshani
    Development of a novel open-source device, 'E-Scope,' to simultaneously record electrophysiology and calcium imaging in freely behaving animals, discovering co-modulation of the cerebellum, and anterior cingulate cortex during social interaction.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova, Daniel E Sturdevant ... Alexander G Pletnev
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
    1. Neuroscience

    A role for cerebellum in the hereditary dystonia DYT1

    Rachel Fremont, Ambika Tewari ... Kamran Khodakhah
    The most common inherited dystonia, DYT1, is likely caused primarily by the dysfunction of the cerebellum rather than the basal ganglia.
    1. Developmental Biology
    2. Neuroscience

    Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish

    Sol Pose-Méndez, Paul Schramm ... Reinhard W Köster
    Purkinje cell-specific ablation demonstrates regeneration of these neurons and functional recovery of the cerebellum during both larval and adult zebrafish.
    1. Neuroscience

    Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age

    Simone Kühn, Anna Mascharek ... IMAGEN Consortium
    Trajectories of adolescent drinking behavior between age 14 and 19 years can be predicted from bilateral striatal and cerebellar grey matter at 14 years of age.