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    1. Neuroscience

    Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

    Sahana Sitaraman et al.
    A protein that is a building block of intercellular bridges between neurons promotes their ability to grow dendrites and make synapses.
    1. Cell Biology
    2. Developmental Biology

    Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

    Sun-Hee Hwang et al.
    Signaling specifically in cilia by a cAMP generating G-protein-coupled receptor directs tissue-specific morphogenesis.
    1. Neuroscience

    Resonating neurons stabilize heterogeneous grid-cell networks

    Divyansh Mittal, Rishikesh Narayanan
    Intrinsic neuronal resonance stabilizes heterogeneous neural networks by suppressing low-frequency perturbations.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov et al.
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Neuroscience

    Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

    Chong Guo et al.
    Purkinje cell collaterals regulate processing in the input layer of the cerebellum by providing fast stochastic GABAA-mediated and slow GABAB-mediated inhibition to a specialized subset of unipolar brush cells.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

    Irene Unterman et al.
    A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.
    1. Neuroscience

    Transcriptomic encoding of sensorimotor transformation in the midbrain

    Zhiyong Xie et al.
    Single-cell RNA-sequencing and neural circuitry analyses reveal that sensorimotor transformation of different behaviors which are performed by separate circuit modules in the superior colliculus are molecularly defined by distinct transcriptomic codes of specific neuron subtypes.
    1. Neuroscience

    A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male mice

    Charlotte Vanacker et al.
    Astrocyte signaling can activate the firing of gonadotropin-releasing hormone neurons and stimulate hormone release.
    1. Cell Biology
    2. Neuroscience

    Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

    Francois Singh et al.
    The most common Parkinson’s disease-associated mutation, LRRK2 G2019S, impairs mitophagy in clinically relevant cells within the mouse brain and this defect can be reversed using a novel LRRK2 inhibitor.
    1. Neuroscience

    The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice

    Elisa Ciaramelli et al.
    During decisions between smaller-immediate rewards and larger rewards available in the future, the ventromedial prefrontal cortex is critical to represent the value of rewards, not the future.