Unprecedented 4D spatiotemporal infant regional cerebral blood flow framework and region-specific physiology–function coupling across infancy were elucidated, highlighting strong physiology–function coupling specifically at the default-mode network to meet extraneuronal metabolic demand for network emergence.

Extracellular matrix signaling constitutively regulates cerebral blood flow in both physiological and pathological settings.

The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.

Genetic studies reveal that mosaic inactivation of ccm2 causes characteristic cerebral cavernous malformations in adult zebrafish and aberrant responses to blood flow that induce the formation of a lethal embryonic multi-cavernous venous malformation.

Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.

Brain temperature and oxygenation vary according to the imaging conditions during two-photon microscopy.

HCO₃^–-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.

A new tracer infusion method is used to confirm that pulsatile cerebrospinal fluid transport into the brain occurs naturally and is driven by the cardiac cycle, not by tracer injection.

Patterns of communication between the thalamus and the cortex are correlated with anesthesia-induced loss of consciousness and recovery.

Analysis of a large Kenyan dataset may resolve previously conflicting studies by identifying polymorphisms which interact to modify the risk of cerebral malaria.