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pathway modulates the
regulation during axial patterning in vertebrates
Tempei Sato et al.
Genetic analyses reveal that the loss of Lin28a causes axial shortening with mild skeletal transformations via decreased PRC1 at Hox genes, establishing a new pathway in the “Hox code.”.
Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development
Kasmir Ramo et al.
The kinase JNK is required in endothelial cells for the development of native collateral arteries.
Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis
Shauna L Houlihan et al.
Analyses based on the mouse model of a human genetic disease reveal that the neuron production of cerebral tissue can be boosted by escalated signaling between neural progenitors and the vasculature.
Immunology and Inflammation
A new genetic strategy for targeting microglia in development and disease
Gabriel L McKinsey et al.
P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.
controls axonal development in distinct populations of cranial and spinal motor neurons
Zhong L Hua et al.
The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation
Pieter R Norden et al.
Genetic and molecular analyses show that FOXC1 and FOXC2 play a role in controlling lymphatic valve maintenance as key mediators of mechanotransduction to control cytoskeletal organization and RhoA/ROCK signaling.
Phylogenetic variation in cortical layer II immature neuron reservoir of mammals
Chiara La Rosa et al.
The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels
Jerome Robert et al.
Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
Chromosomes and Gene Expression
Trisomy 21 consistently activates the interferon response
Kelly D Sullivan et al.
Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.
Microbiology and Infectious Disease
A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults
Nguyen TH Mai et al.
Adjunctive aspirin may reduce new brain infarcts and deaths in the first 60 days of treatment for HIV-uninfected adults with tuberculous meningitis.
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