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Chromosomes and Gene Expression
Immunology and Inflammation
SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX
Allison R Wagner, Chi G Weindel ... Kristin L Patrick
The splicing factor SRSF6 helps regulate antiviral immunity and mitochondrial membrane integrity by balancing the abundance of two alternatively spliced isoforms of the apoptotic protein BAX.
Cancer Biology
Cell Biology
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
Chiho Kim, Xu-Dong Wang, Yonghao Yu
Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.
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