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    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth, Kristin L Muench ... Theo D Palmer
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Ecology
    2. Epidemiology and Global Health

    Physiology and ecology combine to determine host and vector importance for Ross River virus

    Morgan P Kain, Eloise B Skinner ... Erin A Mordecai
    The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a mitochondrial ATP synthase with bound native cardiolipin

    Alexander Mühleip, Sarah E McComas, Alexey Amunts
    The atomic model of a mitochondrial ATP synthase dimer underlies functions of its specific protein constituents and boundary cardiolipins.
  1. Early-career researcher travel grants 2018: Seven more authors selected

    Each will receive up to $1,000 to help them gain exposure and recognition for their work.
    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson, Susan Wyllie ... Alan H Fairlamb
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    1. Microbiology and Infectious Disease

    Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

    Sem H Jacobs, Eva Dóró ... Maria Forlenza
    Transparent zebrafish, reveal the occurrence of foamy macrophages during an extracellular trypanosome infection and their association with an exacerbated inflammatory response.
    1. Ecology
    2. Chromosomes and Gene Expression

    Emerging Technology: Concerning RNA-guided gene drives for the alteration of wild populations

    Kevin M Esvelt, Andrea L Smidler ... George M Church
    Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
    1. Developmental Biology

    Three-dimensional reconstruction of a whole insect reveals its phloem sap-sucking mechanism at nano-resolution

    Xin-Qiu Wang, Jian-sheng Guo ... Chuan-Xi Zhang
    3D reconstruction for an insect provides new internal structures at nanometer resolution, and the reconstructed feeding insect reveals unexpected contraction of stylet protractors and suggested a novel phloem sap-sucking model.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Mari Nishino, Jonathan W Choy ... Jack Taunton
    Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.
    1. Immunology and Inflammation

    Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection

    Ana-Carolina Oliveira, João Francisco Gomes-Neto ... Maria Bellio
    Development of a robust Th1 response to infection against an intracellular parasite requires T-cell intrinsic MyD88 signaling, mostly through the upstream IL-18 receptor, for the induction of genes involved in proliferation, cytokine production and migration.