5,124 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Silvia N Kariuki, Alexander W Macharia ... Thomas N Williams
    Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.
    1. Cell Biology

    KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

    Anthony A Ruberto, Aline Gréchez-Cassiau ... Michèle Teboul
    Krüppel-like factor 10 coordinates the hepatic circadian transcriptome and protects the liver from the adverse effects of increased sugar consumption.
    1. Cell Biology

    Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies

    Mathieu C Husser, Nhat P Pham ... Alisa Piekny
    The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.
    1. Epidemiology and Global Health
    2. Medicine

    Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

    Surabhi Yadav, Olivia Delau ... Ricardo Azziz
    Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

    Dmitry Ter-Ovanesyan, Tal Gilboa ... David R Walt
    A novel immunoassay for ApoB-100, the main protein component of lipoproteins, enables the development of methods to enrich extracellular vesicles from human plasma while depleting both lipoproteins and free proteins.
    1. Medicine

    Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge

    Anirban Sinha, René Lutter ... Edgar Delgado Eckert
    Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

    Scott D Hansen, Albert A Lee ... Jay T Groves
    Dimerization promotes nonlinear kinetics in PIP5K-dependent lipid phosphorylation reactions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

    Kathryn Milne, Alasdair Ivens ... Philip J Spence
    Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
    1. Neuroscience

    Diminished responses to bodily threat and blunted interoception in suicide attempters

    Danielle C DeVille, Rayus Kuplicki ... Sahib S Khalsa
    People who have attempted suicide exhibit blunted sensory processing during breathing and pain perturbations, as well as lower heartbeat perception accuracy and reduced mid/posterior insula activity during interoceptive attention.
    1. Neuroscience

    Automated long-term recording and analysis of neural activity in behaving animals

    Ashesh K Dhawale, Rajesh Poddar ... Bence P Ölveczky
    A new automated system for recording and analyzing neural activity in behaving animals over months-long time-scales offers new perspectives on how neural circuits underlie processes such as learning, development, and recovery from brain injury.

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