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    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

    Andrew James Kerr Conlan, Martin Vordermeier ... James LN Wood
    Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.
    1. Developmental Biology

    Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors

    Diana Rodrigues, Yoan Renaud ... Maneesha S Inamdar
    Comprehensive developmental in situ analysis of the Drosophila lymph gland provides markers highlighting blood progenitor diversity and reveals that JAK-STAT signaling prevents posterior progenitor differentiation, promoting survival after immune challenge.
    1. Immunology and Inflammation

    Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Nils Landegren, Lindsey B Rosen ... Olle Kämpe
    We are writing to comment on the study by Meyer et al., 2016 on disease-ameliorating autoantibodies.
    1. Epidemiology and Global Health
    2. Medicine

    Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

    Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
    A full radical curative dose of primaquine can be given to fully glucose-6-phosphate dehydrogenase-deficient males safely using an ascending dose regimen.
    1. Microbiology and Infectious Disease

    CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

    Kui Xu, Yanrong Zhou ... Kui Li
    The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing

    Raquel Granell, John A Curtin ... Adnan Custovic
    Using unique data from five longitudinal UK birth cohorts, four distinct subsets of genetic variants were identified as differentially associated across wheezing phenotypes from infancy to adolescence with little evidence of genetic associations spanning across different phenotypes.
    1. Biochemistry and Chemical Biology

    Control of cyclic oligoadenylate synthesis in a type III CRISPR system

    Christophe Rouillon, Januka S Athukoralage ... Malcolm F White
    Generation of the anti-viral second messenger cyclic oligoadenylate by type III CRISPR systems is tightly controlled in response to viral RNA load and sequence.
    1. Neuroscience

    Atypical intrinsic neural timescale in autism

    Takamitsu Watanabe, Geraint Rees, Naoki Masuda
    Atypical intrinsic neural timescales in the sensory cortex and caudate were associated with local grey matter volume, and linked with the severity of autism.
    1. Developmental Biology

    Tracking cell lineages in 3D by incremental deep learning

    Ko Sugawara, Çağrı Çevrim, Michalis Averof
    Incremental deep learning enables accurate tracking of cell lineages in 3D with a modest investment in time and effort.
    1. Epidemiology and Global Health
    2. Plant Biology

    Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

    Elizabeth A Savory, Skylar L Fuller ... Jeff H Chang
    The horizontal acquisition of virulence plasmids is potentiated by production practices in plant nurseries and is sufficient to transition Rhodococcus from being beneficial to being pathogenic.