5,668 results found
    1. Structural Biology and Molecular Biophysics

    BK channel inhibition by strong extracellular acidification

    Yu Zhou et al.
    Analysis of iconic and gating currents of wild type and mutated BK channels reveals a strong inhibition of this channel by extracellular acidification and elucidates the underlying mechanism that is potentially applicable to other voltage-dependent cation channels.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

    Nan Liu et al.
    C-terminus mediated inhibition is one emerging modality of intervention for L-type Ca2+ channels, which coordinate multiple motifs to acutely tune Ca2+ current and Ca2+ influx down to the lower limits preset by end-stage Ca2+-dependent inactivation.
    1. Structural Biology and Molecular Biophysics

    Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

    Samuel G Usher et al.
    Simultaneous measurements of ligand binding and channel currents are used to understand gating of the ATP-sensitive K+ channel.
    1. Biochemistry and Chemical Biology

    Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

    Sarah K Stumper et al.
    Single-molecule observations reveal a mechanism that may be used by multiple competing regulatory proteins to control ribosomal RNA production during rapid bacterial cell growth.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu et al.
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
    1. Cell Biology

    Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

    Shekhar Srivastava et al.
    The mammalian potassium channel KCa3.1, which is important for T- and B-cell activation, is inhibited by cytoplasmic copper, mediated by a histidine residue (His358) that is phosphorylated to activate the channel.
    1. Structural Biology and Molecular Biophysics

    The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

    Susanne Rinné et al.
    A combined systematic alanine scanning and molecular modelling approach reveals the molecular basis for an allosteric inhibition mechanism of K+-flux gating in K2P channels.
    1. Neuroscience

    Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

    Seungkyu Lee et al.
    A cationic molecule derived from an uncharged Cav2.2 calcium channel inhibitor powerfully inhibits both sodium and calcium channels with extracellular application and inhibits both pain and neurogenic inflammation.
    1. Structural Biology and Molecular Biophysics

    Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

    Demeng Sun et al.
    Mambalgin1 binds to the thumb domain of human ASIC1a channel and inhibits the channel through hindering the proton-induced transitions from the resting closed state to the active and/or desensitized state.
    1. Neuroscience

    Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

    Doreen Badheka et al.
    Electrophysiological experiments, Ca2+ imaging, and behavioral studies in mice identify the TRPM3 ion channel as a novel target of G-protein βγ subunits.

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