9,775 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

    Christopher G Jacob et al.
    Large-scale genetic surveillance of malaria implemented by National Malaria Control Programmes informs public health decision makers about the spread of strains resistant to antimalarials.
    1. Neuroscience

    A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

    Meng Kuan Lin et al.
    A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Neuroscience

    M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

    Sara Fernández-García et al.
    M2 cortex-dorsolateral striatum circuit is functionally altered in Huntington's disease and, by boosting its activity, we reverse symptoms at behavioral, physiological, and morphological level in symptomatic mice.
    1. Neuroscience

    Luqin-like RYamide peptides regulate food-evoked responses in C. elegans

    Hayao Ohno et al.
    Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.
    1. Neuroscience

    5'-UTR SNP of FGF13 causes translational defect and intellectual disability

    Xingyu Pan et al.
    A 5'-UTR SNP of FGF13 impairs PTBP2 interacting with FGF13 mRNA, leading to reduced FGF13 translation and deficits in brain development and cognitive functions.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

    Jiahui Si et al.
    Lifestyle interventions and statins may target different components of the lipid profile, suggesting that they are not redundant strategies but could be combined for better benefits.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

    Alexandre Giraud-Gatineau et al.
    The anti-tuberculosis drug bedaquiline reprograms human macrophages into potent bactericidal phagocytes, which are able to control bacterial infection.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

    Maeva Dupont et al.
    Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.

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