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    1. Neuroscience

    Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

    Austin L Reese, Ege T Kavalali
    Individual neurons can adjust the strength of their synapses by using spontaneous calcium influx through NMDA receptors to trigger the release of additional calcium from intracellular stores, which can in turn be used to regulate protein synthesis.
    1. Human Biology and Medicine

    Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

    Chelsea Hepler et al.
    Fibro-inflammatory progenitors represent a subpopulation of perivascular cells in visceral adipose tissues of mice that promote inflammation and fibrosis.
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe et al.
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

    Chee Wai Chua et al.
    Analyses of genetically engineered mouse models reveal the androgen receptor-independent properties of a luminal stem/progenitor cell in the prostate epithelium, and its ability to serve as a cell of origin for castration-resistant prostate cancer.
    1. Microbiology and Infectious Disease

    Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

    Aspen T Reese et al.
    Disturbing the microbiota with antibiotics alters gut redox state via changes in electron acceptor availability, setting the stage for post-antibiotic succession.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration

    Robert G Hesse et al.
    Evolution of tumor suppressor genes can involve a trade-off because the acquisition of certain anti-cancer characteristics diminishes the ability to regenerate damaged tissue.
    1. Neuroscience

    Decision Making: Remembering to choose the future

    Lesley K Fellows
    A brain region known as the hippocampus is required when people assess different options before making a value-based choice.
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    1. Evolutionary Biology

    Paleontology: These feet were made for walking

    William L Jungers
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    1. Neuroscience

    Sound localization: These are not the neurons you are looking for

    Victor Benichoux, Daniel J Tollin
    Studies that looked into how the auditory brainstem processes the difference in the intensity of a sound as it reaches each ear may have wrongly assumed which neurons were being recorded.
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