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Predators may amplify multiple-host parasite spreading in systems with multiple transmission routes.

Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.

A collaboration between several pharmaceutical companies provides a unique resource of high-quality chemical probes and associated data from the companies to the academic community.

Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.

Subterranean fossil bone hosts a living microbiome different from the surrounding sediment without evidence of original protein preservation.

With mathematical modeling being an important source of insight for microbial communities, we may need to move beyond commonly-used pairwise models that do not capture microbial interactions.

A potent and selective DYRK2 inhibitor has been developed and used as a chemical tool to reveal eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and stromal interaction molecule 1 (STIM1) are new substrates for DYRK2.

Boosting the function of translation factor eIF2B by chronic small molecule administration prevents pathology in a neurodegenerative model of Vanishing White Matter disease characterized by a maladaptive stress response.

The social amoeba Dictyostelium discoideum employs a terpene synthase-cytochrome P450 metabolic gene cluster to produce a novel trisnorsesquiterpene discodiene.

Caged, photoactivatible sphingosine localized to mitochondria permits demonstration of the importance of subcellular localization on lipid metabolism and signaling.