A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
Single-nociceptor tracing reveals a novel somatotopic organization for the mammalian pain system, and physiological recordings and peripheral optogenetic behavior assays suggest that it is a possible mechanism underlying region-specific pain sensation.
A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
The three-dimensional structures of 50 sensory cilia present in the head of the adult C. elegans hermaphrodite have been reconstructed to provide a foundation for investigations into the mechanisms by which the diversity of cilia structures is generated and how this structural diversity is related to specific sensory neuron functions.