Interleukin-1 activates RhoA/ROCK signaling, which drives the enrichment of actin bundles at the cell-cell junctions, preventing SARS-CoV-2 spreading via syncytia formation.
Oversized mammalian cells reduce their growth efficiency by activating global protein degradation, which functions in parallel with the cell size checkpoints, to promote cell size homeostasis.
Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.
Kira A Cozzolino, Lynn Sanford ... Dylan J Taatjes
The Mediator-associated kinases CDK8 and CDK19 help drive inflammatory responses to interferon, and it is discovered that kinase-dependent transcriptional responses manifest in part through splicing changes and lipid metabolites.
Marina Padilha, Victor Nahuel Keller ... Gilberto Kac
A panel of serum biomarkers, including dietary and microbial-derived metabolites related to the gut-brain axis, were identified as potential for tracking children at risk of early childhood developmental delays.
