160 results found
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz et al.
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.
    1. Neuroscience

    Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

    Kristopher McEown et al.
    Loss of REM sleep increases sucrose and fat consumption in mice; and inhibiting the prefrontal cortex reverses the increased consumption of sucrose, but not fat, following REM sleep loss.
    1. Neuroscience

    Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat

    Fabien Alcaraz et al.
    Adaptive decision-making critically depends on antiparallel flows conveying distinct information within thalamocortical circuits, highlighting directionality of functional exchanges as a neural principle potentially at play in virtually any brain circuit with reciprocal projections.
    1. Neuroscience

    Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

    Xiang-Shan Yuan et al.
    Rostral and central striatum controls slow-wave sleep during active phase in mice.
    1. Neuroscience

    An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice

    Justin N Siemian et al.
    A small population of lateral hypothalamic neurons detects pain and can be activated to suppress pain-related behavioral adaptations and the unpleasantness associated with pain in mice.
    1. Neuroscience

    Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice

    Srikanta Chowdhury et al.
    Subtraction analysis using novel Orexin-Flp mice isolated physiological importance of orexin peptides.
    1. Neuroscience

    Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons

    Filipe Nascimento et al.
    The pairing of chemogenetic and electrophysiological approaches reveals mechanisms by which cholinergic synapses modulate the final motor output of the nervous system.
    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary et al.
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
    1. Neuroscience

    nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

    Christina T Echagarruga et al.
    The diameter of cortical arteries is not controlled by the overall neural activity, but rather by a subset of specialized neurons.

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