7 results found
    1. Cell Biology

    Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy

    Svasti Haricharan et al.
    The transcription factor STAT5 mediates the increased breast cancer risk associated with a late age pregnancy, but intermittent anti-STAT5 treatment can lower this risk and thus prevent breast cancer.
    1. Cell Biology

    Carcinogenesis: Targeting the link between late pregnancy and breast cancer

    Balabhadrapatruni VSK Chakravarthi, Sooryanarayana Varambally
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    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

    Jimmy L Zhao et al.
    Chronic and excessive inflammation can lead to exhaustion of the supply of hematopoietic stem cells and to myeloid malignancies in mice, mimicking important aspects of the myelodysplastic syndrome found in humans.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank

    Paul Carter et al.
    Genetic evidence in humans suggests that statins reduce cancer risk via a cholesterol-independent pathway.
    1. Computational and Systems Biology

    Dynamics of preventive vs post-diagnostic cancer control using low-impact measures

    Andrei R Akhmetzhanov, Michael E Hochberg
    A model based on empirical parameter estimates predicts that arresting cancer cell growth by less than 1% per day will produce optimal outcomes in preventing life-threatening cancers, and that such preventive measures are generally more successful than post-diagnostic interventions.
    1. Cancer Biology
    2. Cell Biology

    AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

    Nicolas Aznar et al.
    An effector of AMPK is essential for the kinase and its pharmacological activators, including Metformin, to strengthen cell-cell junctions and preserve epithelial cell polarity and barrier functions in the face of energetic stress, as well as to suppress oncogenesis.

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