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    1. Neuroscience

    Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

    MinHyuk Lee, Se Hoon Park ... KyeongJin Kang
    A hyperpolarization-activated cation channel, counteracting membrane depolarization, delimits the excitability of receptor neurons subjected to naturally prolonged stimulation to preserve the function of neighboring receptor neurons in Drosophila gustation.
    1. Genetics and Genomics
    2. Neuroscience

    The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

    Yifei Weng, Shiyi Zhou ... Coleen T Murphy
    Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Deciphering the chemical language of inbred and wild mouse conspecific scents

    Maximilian Nagel, Marco Niestroj ... Marc Spehr
    Parallel chemical and physiological profiling of conspecific chemosensory communication in mice identifies both common and unique strategies for vomeronasal signaling of sex and strain.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

    Balázs István Tóth, Bahar Bazeli ... Thomas Voets
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S. Thum
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Evolutionary Biology
    2. Genetics and Genomics

    The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in Drosophila melanogaster

    Nora C Brown, Benjamin Gordon ... Mariana Federica Wolfner
    A functional genetics approach reveals a novel role for odorant binding proteins in post-mating processes, with complex mechanisms of evolutionary change across closely related insect species.
    1. Evolutionary Biology
    2. Medicine

    Taste shaped the use of botanical drugs

    Marco Leonti, Joanna Baker ... Julie Hawkins
    Plant drugs used by ancient Graeco-Roman societies have tastes and flavours that predict how they were used therapeutically.
    1. Ecology
    2. Evolutionary Biology

    Sensory collectives in natural systems

    Hannah J Williams, Vivek H Sridhar ... Amanda D Melin
    A synthetic, prospective article considers how the fields of sensory ecology and collective behaviour can combine when considering animal collective movements and interactions, and how these fields can inspire each other to advance understanding of animal behaviour, adaptation and evolution.
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete