214 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto et al.
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber et al.
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.
    1. Cell Biology

    Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons

    Adria Razzauti, Patrick Laurent
    Disposal of ciliary proteins via ectosomes budding from cilia tip or cilia base acts as a safeguard mechanism when cilia trafficking functions are impaired.
    1. Genetics and Genomics

    NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

    Gabriel A Guerrero et al.
    Separate genetic pathways mediate longevity, pathogen resistance, and cell-nonautonomous regulation of xenobiotic detoxification in chemosensory defective Caenorhabditis elegans mutants.
    1. Neuroscience

    A unified platform to manage, share, and archive morphological and functional data in insect neuroscience

    Stanley Heinze et al.
    The InsectBrain Database is a novel, freely available software tool designed to accelerate research in the field of insect neuroscience and to improve implementation of open data concepts.
    1. Neuroscience

    Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

    Cesar Nava Gonzales et al.
    A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.
    1. Physics of Living Systems

    Ciliary chemosensitivity is enhanced by cilium geometry and motility

    David Hickey et al.
    Chemical receptors located on cilia can achieve particle capture rates that are many times higher than receptors located on a flat epithelial surface.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon et al.
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.
    1. Developmental Biology
    2. Neuroscience

    Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

    Roger Revilla-i-Domingo et al.
    Molecular, cellular and behavioral genetic approaches in Platynereis dumerilii indicate that r-Opsins can act as ancient, light-dependent modulators of mechanosensation, and suggest that light-independent mechanosensory roles of r-Opsins evolved secondarily.
    1. Neuroscience

    Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning in mice

    Haneen Kayyal et al.
    aIC to mPFC connections are correlative and necessary both for taste novelty behavior and learning while the reciprocal connection from mPFC to aIC is correlative and necessary for novelty behavior.

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