163 results found
    1. Cell Biology

    Quantitative regulation of the dynamic steady state of actin networks

    Angelika Manhart et al.
    Cells are able to control the actin network length and steering by adjusting geometric, structural, or biochemical parameters such as ADF/Cofilin and actin concentrations, and network width.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulating G protein-coupled receptors by topological inversion

    Bray Denard et al.
    Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.
    1. Developmental Biology
    2. Neuroscience

    TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization

    Leo TH Tang et al.
    The DMA-1/LRR-TM cell surface receptor signals through partially redundant pathways to cell-autonomously pattern dendrites, including by directly forming a complex with both the TIAM-1/GEF and ACT-4/Actin.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao et al.
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Microbiology and Infectious Disease

    Quorum sensing controls Vibrio cholerae multicellular aggregate formation

    Matthew Jemielita et al.
    A quorum-sensing-controlled program of multicellularity, aggregation, is identified in Vibrio cholerae, which may be important for transitions between the marine niche and the human host.
    1. Developmental Biology
    2. Neuroscience

    Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

    Ankita Ravi Vaswani et al.
    The first comprehensive insight into speed, trajectory and morphology profiles of tangentially migrating dopaminergic neurons and the alterations in their migratory behavior in absence of Reelin signaling.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria

    Joshua S MacCready et al.
    Carboxysomes, the carbon-fixation machinery of cyanobacteria, are equidistantly-positioned by dynamic gradients of the protein McdA on the nucleoid that emerge through interaction with a previously unidentified carboxysome factor, McdB.
    1. Stem Cells and Regenerative Medicine

    Stem cells repurpose proliferation to contain a breach in their niche barrier

    Kenneth Lay et al.
    Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting mutational routes to new adaptive phenotypes

    Peter A Lind et al.
    A combination of genetics, experimental evolution and mathematical modelling defines information necessary to predict the outcome of short-term adaptive evolution.
    1. Physics of Living Systems

    Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation

    Anamika Agrawal et al.
    A quantitative analysis of glucose-dependent transport regulation indicates that mitochondrial accumulation in regions of high nutrient availability can enhance metabolism in neuronal axons under physiologically relevant conditions.

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