232 results found
    1. Cancer Biology

    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

    Carlos J Diaz Osterman et al.
    Genomic gains in ovarian cancer can promote cisplatin resistance via a FAK, Wnt/beta-catenin and Myc signaling pathway supporting pluripotency genes and tumorspheres that can acquire FAK dependence for survival.
    1. Biochemistry and Chemical Biology

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita et al.
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
    1. Computational and Systems Biology

    Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

    Brittany Rosener et al.
    Bacterial evolutionary adaptation to two chemotherapy drugs can lead to changes in bacterial metabolism and impact drug toxicity in a worm host.
    1. Cancer Biology

    Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

    Jordan F Hastings et al.
    Overlaying single cell readouts of cell cycle and apoptosis onto a multidimensional analysis of pulsed cisplatin signalling dynamics reveals targetable mechanisms of platinum resistance in lung adenocarcinoma.
    1. Cancer Biology

    Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

    Shawn McGuirk et al.
    Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.
    1. Cancer Biology
    2. Immunology and Inflammation

    CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

    Andrea Walens et al.
    CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.
    1. Cancer Biology
    2. Cell Biology

    Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

    Giulia Fianco et al.
    Retention of Caspase-8 confers a selective advantage to glioblastoma and represents a novel therapeutic target.
    1. Cancer Biology
    2. Neuroscience

    Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

    Peter M LoCoco et al.
    Stimulation of the rate-limiting enzyme in the NAD salvage pathway protected against neurotoxicity and subsequent peripheral neuropathy associated with the widely utilized anticancer drug, paclitaxel.
    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan et al.
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    1. Cancer Biology

    MELK expression correlates with tumor mitotic activity but is not required for cancer growth

    Christopher J Giuliano et al.
    Cancer cells can grow in vitro and in vivo in the absence of maternal embryonic leucine zipper kinase (MELK).

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