489 results found
    1. Cell Biology
    2. Medicine

    Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

    Hosni Cherif et al.
    Targeting senescent cells in human intervertebral discs, using senotherapeutics, provides a potential therapeutic strategy to prevent or reduce disc degeneration and pain.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

    Lisa Landskron et al.
    Genetic analyses uncovered that the asymmetrically long non-coding RNA cherub is required for brain tumor growth.
    1. Chromosomes and Gene Expression

    Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

    Patrick D Cherry et al.
    RNA decay is used at multiple points in the budding yeast unfolded protein response to regulate its suppression and activation, and possibly its attenuation.
    1. Chromosomes and Gene Expression

    Viral-induced alternative splicing of host genes promotes influenza replication

    Matthew G Thompson et al.
    Infection of human cells by influenza A virus induces changes in the alternative splicing of host genes that, in turn, promote viral replication.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Stem Cell Tumors: Cherub versus brat

    Jennifer A Malin, Claude Desplan
    A long non-coding RNA molecule called cherub is a driver of tumor development.
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    1. Epidemiology and Global Health

    Epidemiology and burden of multidrug-resistant bacterial infection in a developing country

    Cherry Lim et al.
    The burden of antimicrobial resistance in Thailand is deteriorating over time, and 19,122 deaths in the country in 2010 were excess deaths caused by multidrug-resistant bacterial infection.
    1. Neuroscience

    Charcot-Marie-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function

    Smita Cherry et al.
    Mutations that reduce the functioning of rab7 may underlie the degeneration of sensory and motor nerves in Charcot-Marie-Tooth 2B disease, which suggests increasing endolysosomal function as a therapy.
    1. Neuroscience

    Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

    Antoine Cherix et al.
    1H-Magnetic resonance spectroscopy at 14T reveals a metabolic signature for anti-depressant-like effects of acetyl-L-carnitine in nucleus accumbens of susceptible mouse.
    1. Neuroscience

    Subretinal mononuclear phagocytes induce cone segment loss via IL-1β

    Chiara M Eandi et al.
    IL-1β release from macrophages might be responsible for the unexplained cone segment loss in retinal degenerative diseases that are associated with subretinal inflammation, such as retinitis pigmentosa or geographic atrophy.
    1. Genetics and Genomics

    The rise and fall of the Phytophthora infestans lineage that triggered the Irish potato famine

    Kentaro Yoshida et al.
    The strain of Phytophthora infestans that caused the Great Famine in the late 1840s was caused by a single genotype that is distinct from, but closely related to, the most prevalent modern genotype.

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