6,990 results found
    1. Neuroscience

    Numerical magnitude, rather than individual bias, explains spatial numerical association in newborn chicks

    Rosa Rugani, Giorgio Vallortigara ... Lucia Regolin
    Spatial numerical association in three-day-old domestic chicks linearly decreases as numerical magnitude increases (2>5>8), supporting the hypothesis that numerical magnitude guides the spatial numerical association.
    1. Developmental Biology

    Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

    Holly Hardy, James GD Prendergast ... Joe Rainger
    Chick optic fissure closure is a powerful new model system for epithelial fusion and has revealed Netrin-1 as a conserved and essential mediator of tissue fusion in multiple contexts.
    1. Neuroscience

    Young domestic chicks spontaneously represent the absence of objects

    Eszter Szabó, Cinzia Chiandetti ... Giorgio Vallortigara
    Without specific training, young chicks represent the absence of objects, showing that the concept of 'nothing' is available to nonhuman animals and does not require linguistic tools, such as negation.
    1. Neuroscience

    Three-dimensional single-cell transcriptome imaging of thick tissues

    Rongxin Fang, Aaron Halpern ... Xiaowei Zhuang
    By integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH), deep learning, optical sectioning, and protocol optimization, thick-tissue 3D MERFISH allows volumetric single-cell transcriptome imaging of thick-tissue samples, broadening the scope of applications of spatial genomics.
    1. Microbiology and Infectious Disease
    2. Immunology and Inflammation

    IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity

    Judith Schick, Meltem Altunay ... Roland Lang
    The expression of DECTIN-2 family C-type lectin receptors on macrophages and monocytes is inhibited by the Th2 cytokine IL-4, which suggests a mechanism for inhibition of Th17 responses to MINCLE-dependent vaccination responses by underlying helminth infection.
    1. Neuroscience

    A cell atlas of the chick retina based on single-cell transcriptomics

    Masahito Yamagata, Wenjun Yan, Joshua R Sanes
    A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.
    1. Neuroscience

    High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex

    Daniel Haenelt, Robert Trampel ... Nikolaus Weiskopf
    In vivo quantitative magnetic resonance imaging at ultra-high magnetic field reveals systematic differences of relaxation parameters (R1) within the human secondary visual cortex at the level of the thin-thick-pale stripes system, which points toward higher cortical myelination of pale stripes.
    1. Physics of Living Systems

    Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

    Xuemeng Zhang, Thomas Kampourakis ... Yin-Biao Sun
    The Frank–Starling law of the heart and its underlying mechanism of length-dependent activation involve distinctive structural changes in both the thin and thick filaments of cardiac muscle cells.
    1. Developmental Biology

    Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

    Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
    A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
    1. Computational and Systems Biology

    Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

    Yuka Takemon, Joel M Chick ... Ron Korstanje
    mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.

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