3,932 results found
    1. Neuroscience

    Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

    Laifu Li et al.
    Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Regional sequencing collaboration reveals persistence of the T12 Vibrio cholerae O1 lineage in West Africa

    Eme Ekeng et al.
    The T12 Vibrio cholerae lineage has been continuously circulating in West Africa since at least 2012, highlighting the importance of regional disease control efforts.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Cell Biology

    Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

    Stephanie E Crilly et al.
    A GPCR activated by the same agonist engages different conformational biosensors at different subcellular locations, suggesting that location-based conformations drive spatial encoding of signaling.
    1. Developmental Biology
    2. Evolutionary Biology

    Early maternal loss leads to short- but not long-term effects on diurnal cortisol slopes in wild chimpanzees

    Cédric Girard-Buttoz et al.
    Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.
    1. Cell Biology

    Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

    Lara Katharina Krüger et al.
    During anaphase B spindle elongation, Klp9 controls the speed of both microtubule sliding and microtubule growth to coordinate the processes and thus maintain spindle stability for faithful chromosome separation.
    1. Medicine

    The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

    Melanie Castro-Mollo et al.
    The hepcidin regulator erythroferrone functions by sequestering BMPs and is an important modulator of bone remodeling, providing new mechanistic insight into how premature osteoporosis persists in optimally transfused β-thalassemic patients.
    1. Ecology
    2. Plant Biology

    Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe

    Ella Katz et al.
    Measurements of specialized metabolites across a population of 800 natural Arabidopsis thaliana accessions revealed different pressures and evolutionary processes that shaped their variation and distribution across Europe.
    1. Evolutionary Biology

    Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers

    Kai He et al.
    Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang et al.
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.

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