118 results found
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

    Irene Gallego Romero et al.
    A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
    1. Ecology
    2. Epidemiology and Global Health

    Personality links with lifespan in chimpanzees

    Drew M Altschul et al.
    Among captive chimpanzees, higher agreeableness males and higher openness females survive longer.
    1. Cell Biology
    2. Developmental Biology

    Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

    Felipe Mora-Bermúdez et al.
    Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.
    1. Evolutionary Biology

    A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

    Michelle C Ward, Yoav Gilad
    Evolutionarily conserved hypoxic stress response genes are depleted for association with expression quantitative trait loci.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression variability in human and chimpanzee populations share common determinants

    Benjamin Jung Fair et al.
    Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.
    1. Neuroscience

    Chimpanzee brain morphometry utilizing standardized MRI preprocessing and macroanatomical annotations

    Sam Vickery et al.
    Openly available structural imaging processing pipeline for chimpanzees including registration templates and macro-anatomical parcellation shows human-like cerebral aging and medial hemispheric organization.
    1. Ecology

    Travel fosters tool use in wild chimpanzees

    Thibaud Gruber et al.
    Travel has a major influence on tool use in wild chimpanzees, suggesting that tool use reduced travel costs during hominid evolution.
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto et al.
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Genetics and Genomics

    Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

    Briana E Mittleman et al.
    A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.
    1. Neuroscience

    Cross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe

    Nicole Eichert et al.
    Cross-species alignment based on cortical myelin content can dissociate cortical expansion and relocation from changes in connectivity profiles in the temporal lobe of higher primates.

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