81 results found
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

    Kevin W Ng et al.
    An ancient integration of an endogenous retroelement in the gene encoding PD-L1 is exapted to generate a soluble form that antagonises the suppressive function of the membrane-bound form.
    1. Microbiology and Infectious Disease

    Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection

    Rachel A Liberatore et al.
    A new animal model permits the in vivo study of HIV-1 entry, as well as the elicitation and antiviral activity of antibodies, in a genetically manipulatable host.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

    Leslie A McCauliff et al.
    Sterol kinetics and cell-based assays reveal a heretofore unknown step in cholesterol trafficking through the endolysosomal compartment, involving a direct functional interaction between NPC2 and lysosbisphosphatidic acid.
    1. Ecology

    Group-specific archaeological signatures of stone tool use in wild macaques

    Lydia V Luncz et al.
    Tool behaviour of long-tailed macaques leaves archaeological signatures that differ between populations despite similar ecological conditions, highlighting the potential for diversity in material culture.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

    Dominik Witzigmann et al.
    The combination of in vitro investigations, the zebrafish screening model and rodent experiments offered a unique approach to optimizing nanoparticles modified with Hepatitis B virus-derived peptides to specifically target hepatocytes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA

    Sasha A Langley et al.
    Genomic polymorphism across centromeric regions of humans is organized into large-scale haplotypes with great diversity, including entire Neanderthal centromeres.
    1. Cell Biology
    2. Evolutionary Biology

    Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

    Matteo Fumagalli et al.
    Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.
    1. Evolutionary Biology

    A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

    Michelle C Ward, Yoav Gilad
    Evolutionarily conserved hypoxic stress response genes are depleted for association with expression quantitative trait loci.
    1. Evolutionary Biology

    Stem Cells: Getting to the heart of cardiovascular evolution in humans

    Alex Pollen, Bryan J Pavlovic
    Differences in the response of cardiomyocytes to oxygen deprivation in humans and chimpanzees may explain why humans are more prone to certain heart diseases.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Independent amylase gene copy number bursts correlate with dietary preferences in mammals

    Petar Pajic et al.
    Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.

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