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Cranial endocasts of fossil and extant lungfish, analysed via tomography and novel principle component analyses designed for use with missing data, show that lungfish forebrain and inner ear regions show the most variation in brain shape evolution through time.

Two acid-sensing members of the degenerin/epithelial sodium channel family play distinct roles in controlling different aspects of rhythmic proton and calcium oscillations in the nematode intestine.

Lowering endosomal pH through inhibition of sodium-hydrogen exchanger 6 corrects the ApoE4-induced Reelin resistance and restores neuronal glutamate receptor trafficking.

Contrary to the high absolute number of white-eyes in other parts of the world, the Indonesian archipelago is the center of phylogenetic diversity of this great speciator.

A phylogeny of all major groups of flatworms based on hundreds of genes sheds new light the early evolution of this important metazoan phylum, with particular significance for the original of vertebrate parasitism.

A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.

The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.

Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.

A novel, overlapping, putatively functional gene in SARS-CoV-2, ORF3d, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus.

Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.